"the greatest mistake we can make in life is to be continually fearing we will make one." -Victor Havel
During my time at Microsoft in the 1st half of the 90's, I used to joke that the reason we were having success was that we just made mistakes faster than anyone else (but tended not to repeat them). The other side of that coin was a willingness to take risks. I think those factors are the reasons why big companies that seemingly have all of the advantages often get beaten by smaller companies.